Gene polymorphisms of interleukin 10 (− 819 C/T and − 1082 G/A) in women with ovarian cancer

Abstract Background Ovarian cancer (OC) is the leading cause of death associated with gynecologic cancer. IL-10 plays an important role in tumorigenesis. We investigated gene polymorphisms OC patients. The current case–control study screened forty-eight women and healthy who did not have OC. genotyping SNPs (− 1082 G > A; rs1800896 − 819 C T; rs1800871) was done by tetra primers sequence-specific primer polymerase chain reaction (SSP-PCR) technique. plasma levels were measured using enzyme-linked immunosorbent assay (ELISA). Results For G/A) polymorphism, (wild allele) significantly increasing risk (OR = 2.054 CI 1.154–3.657; P < 0.05), while A (variant AA genotype decreasing 0.487 0.273–0.867; 0.05) 0.15; 95% 0.04–0.63; respectively. 819C/T) polymorphisms, T allele (TT, CT genotypes) 2.800 1.577–5.037; 18.33 3.46–97.20; 0.001), 9.44 2.52–35.40; respectively, 0.357 0.199–0.642; 0.05). haplotype analysis for shows GT 50.09 6.34–395.92; 0.001). substantially correlated level ( r 0.457; p There no linkage disequilibrium (LD) between IL 10 G/A C/T D′ 0.1315, 2 0.016; NS). statistically significant positive relationship existed CA125 ALT albumin showed a strong negative association whereas correlation IL10 BUN, AST, T. Bil., TLC, PLT, Cr., HB has any value Conclusions Overall, this supports ovarian